16 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Kent town | 1 | 12,666 | 12,899 | -0.7% | 313 | 40.53 | Town |
| Albion town | 2 | 6,952 | 7,528 | 0.48% | 275 | 25.26 | Town |
| Ridgeway town | 3 | 6,401 | 6,578 | -0.47% | 128 | 50.03 | Town |
| Medina | 4 | 5,837 | 6,009 | -0.58% | 1,769 | 3.30 | Village |
| Albion | 5 | 5,788 | 5,642 | 0.5% | 1,982 | 2.92 | Village |
| Shelby town | 6 | 4,804 | 4,873 | -0.15% | 104 | 46.39 | Town |
| Murray town | 7 | 4,710 | 4,812 | -0.3% | 152 | 31.06 | Town |
| Clarendon town | 8 | 3,361 | 3,305 | 0.66% | 95 | 35.22 | Town |
| Gaines town | 9 | 3,164 | 3,219 | -0.47% | 92 | 34.42 | Town |
| Carlton town | 10 | 2,796 | 2,822 | -0.11% | 64 | 43.61 | Town |
| Kendall town | 11 | 2,563 | 2,611 | -0.39% | 78 | 32.86 | Town |
| Yates town | 12 | 2,492 | 2,554 | -0.48% | 67 | 37.39 | Town |
| Albion town | 13 | 2,060 | 2,018 | 0.34% | 44 | 47.29 | Town |
| Barre town | 14 | 1,803 | 1,833 | -0.17% | 33 | 55.04 | Town |
| Holley | 15 | 1,708 | 1,763 | -0.64% | 1,347 | 1.27 | Village |
| Lyndonville | 16 | 777 | 797 | -0.51% | 759 | 1.02 | Village |
Kent town is the largest city in Orleans County, with a population of 12,666.
Lyndonville is the smallest city in Orleans County.
There are 16 cities in Orleans County, New York.