4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Piedmont | 1 | 1,843 | 1,887 | -0.49% | 865 | 2.13 | City |
| Greenville | 2 | 436 | 446 | -0.46% | 646 | 0.68 | City |
| Williamsville | 3 | 270 | 275 | -0.37% | 836 | 0.32 | City |
| Mill Spring | 4 | 155 | 159 | -0.64% | 352 | 0.44 | Village |
Piedmont is the largest city in Wayne County, with a population of 1,843.
Mill Spring is the smallest city in Wayne County.
There are 4 cities in Wayne County, Missouri.