11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Caruthersville | 1 | 5,022 | 5,536 | -2.01% | 974 | 5.16 | City |
| Hayti | 2 | 2,200 | 2,475 | -2.44% | 958 | 2.30 | City |
| Steele | 3 | 1,637 | 1,844 | -2.44% | 757 | 2.16 | City |
| Hayti Heights | 4 | 457 | 512 | -2.35% | 466 | 0.98 | City |
| Cooter | 5 | 306 | 345 | -2.55% | 1,037 | 0.29 | City |
| Wardell | 6 | 271 | 308 | -2.52% | 961 | 0.28 | Town |
| Holland | 7 | 172 | 194 | -2.27% | 1,030 | 0.17 | Town |
| Pascola | 8 | 80 | 87 | -1.23% | 500 | 0.16 | Village |
| Deering | 9 | 76 | 67 | 7.04% | 258 | 0.29 | CDP |
| Homestown | 10 | 68 | 77 | -2.86% | 553 | 0.12 | City |
| Bragg City | 11 | 59 | 68 | -3.28% | 289 | 0.20 | Town |
Caruthersville is the largest city in Pemiscot County, with a population of 5,022.
Bragg City is the smallest city in Pemiscot County.
There are 11 cities in Pemiscot County, Missouri.