2 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Perryville | 1 | 8,471 | 8,558 | -0.2% | 1,038 | 8.16 | City |
| Frohna | 2 | 243 | 245 | 0% | 269 | 0.90 | City |
Perryville is the largest city in Perry County, with a population of 8,471.
Frohna is the smallest city in Perry County.
There are 2 cities in Perry County, Missouri.