15 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Odessa | 1 | 5,658 | 5,608 | 0.18% | 1,381 | 4.10 | City |
| Higginsville | 2 | 4,715 | 4,819 | -0.44% | 1,251 | 3.77 | City |
| Lexington | 3 | 4,536 | 4,658 | -0.53% | 868 | 5.23 | City |
| Concordia | 4 | 2,325 | 2,377 | -0.43% | 1,269 | 1.83 | City |
| Waverly | 5 | 807 | 792 | 0.37% | 640 | 1.26 | City |
| Wellington | 6 | 761 | 743 | 0.53% | 698 | 1.09 | City |
| Dover township | 7 | 475 | 470 | 0.42% | 10 | 47.49 | Township |
| Corder | 8 | 426 | 418 | 0.47% | 1,197 | 0.36 | City |
| Alma | 9 | 388 | 402 | -0.77% | 1,411 | 0.28 | City |
| Bates City | 10 | 232 | 217 | 1.31% | 214 | 1.08 | City |
| Mayview | 11 | 218 | 210 | 0.93% | 1,397 | 0.16 | City |
| Napoleon | 12 | 207 | 212 | -0.48% | 118 | 1.75 | City |
| Emma | 13 | 203 | 200 | 0.5% | 346 | 0.59 | City |
| Fleming | 14 | 115 | 114 | 0% | 213 | 0.54 | City |
| Dover | 15 | 87 | 84 | 1.16% | 433 | 0.20 | Town |
Odessa is the largest city in Lafayette County, with a population of 5,658.
Dover is the smallest city in Lafayette County.
There are 15 cities in Lafayette County, Missouri.