9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Noel | 1 | 2,210 | 2,135 | 0.68% | 1,091 | 2.02 | City |
| Anderson | 2 | 2,090 | 2,024 | 0.63% | 919 | 2.27 | City |
| Goodman | 3 | 1,338 | 1,198 | 2.14% | 1,008 | 1.33 | City |
| Southwest City | 4 | 1,001 | 920 | 1.62% | 684 | 1.46 | Town |
| Pineville | 5 | 848 | 793 | 1.31% | 258 | 3.29 | City |
| Jane | 6 | 408 | 357 | 2.51% | 137 | 2.98 | Town |
| Lanagan | 7 | 389 | 374 | 0.78% | 414 | 0.94 | Town |
| Rocky Comfort | 8 | 194 | 96 | 7.18% | 350 | 0.55 | CDP |
| Ginger Blue | 9 | 34 | 33 | 0% | 130 | 0.26 | Village |
Noel is the largest city in McDonald County, with a population of 2,210.
Ginger Blue is the smallest city in McDonald County.
There are 9 cities in McDonald County, Missouri.