27 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Baxter Springs | 1 | 3,796 | 3,881 | -0.45% | 1,205 | 3.15 | City |
| Columbus | 2 | 2,840 | 2,914 | -0.53% | 1,167 | 2.43 | City |
| Galena | 3 | 2,748 | 2,758 | -0.07% | 597 | 4.60 | City |
| Garden township | 4 | 2,696 | 2,738 | 0.04% | 93 | 28.91 | Township |
| Spring Valley township | 5 | 1,002 | 1,018 | 0.1% | 21 | 47.05 | Township |
| Riverton | 6 | 679 | 893 | -2.44% | 302 | 2.25 | CDP |
| Lowell township | 7 | 669 | 680 | 0.15% | 52 | 12.87 | Township |
| Ross township | 8 | 619 | 633 | -0.16% | 11 | 54.06 | Township |
| Crawford township | 9 | 590 | 597 | 0.17% | 16 | 36.35 | Township |
| Pleasant View township | 10 | 559 | 568 | 0% | 11 | 52.37 | Township |
| Weir | 11 | 557 | 569 | -0.36% | 489 | 1.14 | City |
| Salamanca township | 12 | 464 | 473 | 0% | 13 | 34.48 | Township |
| Chicopee | 13 | 383 | 533 | -0.52% | 121 | 3.16 | CDP |
| McCune | 14 | 368 | 373 | -0.27% | 1,157 | 0.32 | City |
| Scammon | 15 | 365 | 372 | -0.27% | 582 | 0.63 | City |
| Lowell | 16 | 328 | 228 | 0.92% | 1,045 | 0.31 | CDP |
| Lyon township | 17 | 318 | 323 | 0% | 6 | 50.15 | Township |
| Lola township | 18 | 295 | 300 | 0% | 7 | 44.44 | Township |
| Neosho township | 19 | 243 | 244 | 0.41% | 4 | 60.62 | Township |
| Mineral township | 20 | 212 | 215 | 0% | 7 | 30.64 | Township |
| Sheridan township | 21 | 203 | 204 | 0% | 3 | 66.75 | Township |
| West Mineral | 22 | 146 | 151 | -0.68% | 433 | 0.34 | City |
| Yale | 23 | 95 | 66 | 6.74% | 96 | 0.99 | CDP |
| Crestline | 24 | 75 | 34 | 7.14% | 42 | 1.78 | CDP |
| Roseland | 25 | 73 | 75 | 0% | 100 | 0.73 | City |
| Hallowell | 26 | 70 | 49 | 7.69% | 81 | 0.86 | CDP |
| Labette | 27 | 53 | 55 | 0% | 237 | 0.22 | City |
Baxter Springs is the largest city in Cherokee County, with a population of 3,796.
Labette is the smallest city in Cherokee County.
There are 27 cities in Cherokee County, Kansas.