8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Florence | 1 | 43,677 | 40,577 | 1.44% | 1,644 | 26.57 | City |
| Underwood-Petersville | 2 | 3,035 | 2,707 | -0.46% | 524 | 5.80 | CDP |
| Rogersville | 3 | 1,451 | 1,285 | 2.33% | 478 | 3.03 | Town |
| Killen | 4 | 1,039 | 1,029 | 0.19% | 513 | 2.02 | Town |
| St. Florian | 5 | 756 | 625 | 3.56% | 170 | 4.45 | Town |
| Lexington | 6 | 740 | 727 | 0.41% | 229 | 3.24 | Town |
| Anderson | 7 | 256 | 253 | 0.39% | 198 | 1.29 | Town |
| Waterloo | 8 | 184 | 181 | 0.55% | 246 | 0.75 | Town |
Florence is the largest city in Lauderdale County, with a population of 43,677.
Waterloo is the smallest city in Lauderdale County.
There are 8 cities in Lauderdale County, Alabama.