13 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Rainbow City | 1 | 10,400 | 10,204 | 0.38% | 405 | 25.65 | City |
| Glencoe | 2 | 5,419 | 5,381 | 0.15% | 319 | 17 | City |
| Hokes Bluff | 3 | 4,786 | 4,440 | 1.46% | 401 | 11.93 | City |
| Centre | 4 | 3,904 | 3,599 | 1.59% | 334 | 11.70 | City |
| Cedar Bluff | 5 | 1,936 | 1,843 | 0.99% | 403 | 4.81 | Town |
| Coats Bend | 6 | 1,343 | 1,063 | -0.22% | 157 | 8.55 | CDP |
| Ballplay | 7 | 1,081 | 1,522 | -2.96% | 46 | 23.55 | CDP |
| Leesburg | 8 | 997 | 967 | 0.61% | 158 | 6.30 | Town |
| Tidmore Bend | 9 | 947 | 1,060 | -2.07% | 98 | 9.62 | CDP |
| Sand Rock | 10 | 605 | 592 | 0.5% | 119 | 5.07 | Town |
| Broomtown | 11 | 218 | 103 | 0.93% | 46 | 4.69 | CDP |
| Gaylesville | 12 | 176 | 171 | 0.57% | 127 | 1.39 | Town |
| Spring Garden | 13 | 116 | 172 | -6.45% | 51 | 2.27 | CDP |
Rainbow City is the largest city in Cherokee County, with a population of 10,400.
Spring Garden is the smallest city in Cherokee County.
There are 13 cities in Cherokee County, Alabama.