6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Aliceville | 1 | 1,981 | 2,166 | -1.83% | 433 | 4.57 | City |
| Gordo | 2 | 1,545 | 1,627 | -1.02% | 475 | 3.25 | Town |
| Reform | 3 | 1,422 | 1,519 | -1.32% | 178 | 8.01 | Town |
| Carrollton | 4 | 952 | 1,017 | -1.35% | 463 | 2.06 | Town |
| Macedonia | 5 | 196 | 199 | -2.97% | 50 | 3.95 | CDP |
| Ethelsville | 6 | 49 | 51 | 0% | 86 | 0.57 | Town |
Aliceville is the largest city in Pickens County, with a population of 1,981.
Ethelsville is the smallest city in Pickens County.
There are 6 cities in Pickens County, Alabama.