14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Oxford | 1 | 22,069 | 22,091 | -0.02% | 692 | 31.88 | City |
| Anniston | 2 | 20,935 | 21,515 | -0.55% | 457 | 45.83 | City |
| Jacksonville | 3 | 14,934 | 14,303 | 0.85% | 1,369 | 10.91 | City |
| Saks | 4 | 10,468 | 10,175 | -0.17% | 860 | 12.18 | CDP |
| Southside | 5 | 9,677 | 9,476 | 0.42% | 506 | 19.11 | City |
| Piedmont | 6 | 4,655 | 4,779 | -0.53% | 474 | 9.82 | City |
| Alexandria | 7 | 3,706 | 4,185 | -0.38% | 333 | 11.13 | CDP |
| Weaver | 8 | 3,324 | 3,338 | -0.09% | 962 | 3.46 | City |
| West End-Cobb Town | 9 | 3,286 | 3,492 | -0.36% | 798 | 4.12 | CDP |
| Choccolocco | 10 | 2,769 | 3,246 | -0.07% | 238 | 11.65 | CDP |
| Ohatchee | 11 | 1,224 | 1,156 | 1.16% | 208 | 5.88 | Town |
| White Plains | 12 | 816 | 541 | 0% | 64 | 12.79 | CDP |
| Hobson City | 13 | 738 | 752 | -0.4% | 706 | 1.05 | Town |
| Nances Creek | 14 | 472 | 380 | 0.85% | 81 | 5.81 | CDP |
Oxford is the largest city in Calhoun County, with a population of 22,069.
Nances Creek is the smallest city in Calhoun County.
There are 14 cities in Calhoun County, Alabama.