4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Kenedy | 1 | 3,345 | 3,489 | -0.86% | 758 | 4.41 | City |
| Karnes City | 2 | 3,112 | 3,111 | 0% | 1,343 | 2.32 | City |
| Runge | 3 | 976 | 900 | 1.56% | 830 | 1.18 | Town |
| Falls City | 4 | 508 | 517 | -0.39% | 570 | 0.89 | City |
Kenedy is the largest city in Karnes County, with a population of 3,345.
Falls City is the smallest city in Karnes County.
There are 4 cities in Karnes County, Texas.