5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Greenwood | 1 | 12,758 | 14,415 | -2.53% | 1,034 | 12.34 | City |
| Itta Bena | 2 | 1,469 | 1,668 | -2.65% | 1,041 | 1.41 | City |
| Mississippi Valley State University | 3 | 874 | 1,029 | -2.35% | 487 | 1.79 | CDP |
| Schlater | 4 | 213 | 235 | -1.84% | 185 | 1.15 | Town |
| Morgan City | 5 | 193 | 208 | -1.53% | 329 | 0.59 | Town |
Greenwood is the largest city in Leflore County, with a population of 12,758.
Morgan City is the smallest city in Leflore County.
There are 5 cities in Leflore County, Mississippi.