11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Centerville | 1 | 5,302 | 5,407 | -0.39% | 1,096 | 4.84 | City |
| Moravia | 2 | 618 | 637 | -0.64% | 526 | 1.18 | City |
| Moulton | 3 | 593 | 608 | -0.5% | 595 | 1 | City |
| Mystic | 4 | 318 | 325 | -0.31% | 108 | 2.94 | City |
| Cincinnati | 5 | 279 | 288 | -0.71% | 159 | 1.76 | City |
| Exline | 6 | 156 | 161 | -0.64% | 157 | 0.99 | City |
| Unionville | 7 | 73 | 75 | 0% | 97 | 0.75 | City |
| Numa | 8 | 69 | 71 | 0% | 156 | 0.44 | City |
| Plano | 9 | 57 | 59 | 0% | 101 | 0.56 | City |
| Rathbun | 10 | 38 | 40 | 0% | 178 | 0.21 | City |
| Udell | 11 | 29 | 31 | 0% | 103 | 0.28 | City |
Centerville is the largest city in Appanoose County, with a population of 5,302.
Udell is the smallest city in Appanoose County.
There are 11 cities in Appanoose County, Iowa.