8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| New Martinsville | 1 | 5,009 | 5,203 | -0.77% | 1,874 | 2.67 | City |
| Paden City | 2 | 2,325 | 2,532 | -1.73% | 2,748 | 0.85 | City |
| Pine Grove | 3 | 333 | 360 | -1.48% | 946 | 0.35 | Town |
| Hundred | 4 | 232 | 256 | -2.11% | 462 | 0.50 | Town |
| Jacksonburg | 5 | 95 | 79 | -5% | 64 | 1.48 | CDP |
| Smithfield | 6 | 92 | 102 | -2.13% | 315 | 0.29 | Town |
| Littleton | 7 | 70 | 184 | -11.39% | 107 | 0.66 | CDP |
| Reader | 8 | 58 | 290 | -28.4% | 62 | 0.93 | CDP |
New Martinsville is the largest city in Wetzel County, with a population of 5,009.
Reader is the smallest city in Wetzel County.
There are 8 cities in Wetzel County, West Virginia.