7 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Kenova | 1 | 2,810 | 3,027 | -1.51% | 2,130 | 1.32 | City |
| Wayne | 2 | 1,367 | 1,437 | -1.01% | 1,158 | 1.18 | Town |
| Ceredo | 3 | 1,299 | 1,404 | -1.59% | 989 | 1.31 | City |
| Lavalette | 4 | 970 | 1,256 | -0.72% | 372 | 2.61 | CDP |
| Fort Gay | 5 | 651 | 676 | -0.76% | 789 | 0.82 | Town |
| Prichard | 6 | 431 | 321 | -1.37% | 389 | 1.11 | CDP |
| Crum | 7 | 133 | 44 | -2.21% | 261 | 0.51 | CDP |
Kenova is the largest city in Wayne County, with a population of 2,810.
Crum is the smallest city in Wayne County.
There are 7 cities in Wayne County, West Virginia.