18 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Mount Pleasant | 1 | 20,279 | 21,729 | -1.41% | 2,626 | 7.72 | City |
| Union charter township | 2 | 11,678 | 11,730 | -0.38% | 415 | 28.17 | Township |
| Chippewa township | 3 | 4,609 | 4,532 | 0.11% | 129 | 35.85 | Township |
| Sherman township | 4 | 3,195 | 3,130 | 0.19% | 92 | 34.72 | Township |
| Coe township | 5 | 3,044 | 3,039 | -0.23% | 84 | 36.16 | Township |
| Isabella township | 6 | 2,177 | 2,148 | 0% | 60 | 36.32 | Township |
| Lake Isabella | 7 | 1,947 | 1,901 | 0.46% | 560 | 3.48 | Village |
| Broomfield township | 8 | 1,898 | 1,869 | 0% | 54 | 34.91 | Township |
| Shepherd | 9 | 1,507 | 1,496 | 0.13% | 1,575 | 0.96 | Village |
| Rolland township | 10 | 1,418 | 1,409 | -0.14% | 40 | 35.76 | Township |
| Weidman | 11 | 1,376 | 1,265 | 2% | 243 | 5.65 | CDP |
| Wise township | 12 | 1,359 | 1,346 | -0.07% | 37 | 36.52 | Township |
| Gilmore township | 13 | 1,335 | 1,320 | 0% | 38 | 35.60 | Township |
| Denver township | 14 | 1,145 | 1,129 | 0% | 31 | 36.41 | Township |
| Rosebush | 15 | 359 | 356 | 0.28% | 404 | 0.89 | Village |
| Winn | 16 | 335 | 421 | 7.03% | 585 | 0.57 | CDP |
| Beal City | 17 | 278 | 258 | -2.11% | 69 | 4.01 | CDP |
| McBride | 18 | 222 | 217 | 0.45% | 572 | 0.39 | Village |
Mount Pleasant is the largest city in Isabella County, with a population of 20,279.
McBride is the smallest city in Isabella County.
There are 18 cities in Isabella County, Michigan.