City | Rank | County | 2024 Pop. |
|---|---|---|---|
| Bennettsville | 1 | Marlboro County | 6,426 |
| Dillon | 2 | Dillon County | 6,239 |
| Cheraw | 3 | Chesterfield County | 4,983 |
| McColl | 4 | Marlboro County | 1,968 |
| Chesterfield | 5 | Chesterfield County | 1,364 |
| Hamer | 6 | Dillon County | 887 |
| McBee | 7 | Chesterfield County | 792 |
| Wallace | 8 | Marlboro County | 624 |
| Little Rock | 9 | Dillon County | 612 |
| Clio | 10 | Marlboro County | 574 |
| Cash | 11 | Chesterfield County | 486 |
| Society Hill | 12 | Darlington County | 428 |
| Bethune | 13 | Kershaw County | 336 |
| Ruby | 14 | Chesterfield County | 322 |
| Patrick | 15 | Chesterfield County | 283 |
| Mount Croghan | 16 | Chesterfield County | 133 |
| Blenheim | 17 | Marlboro County | 108 |
| Tatum | 18 | Marlboro County | 70 |