City | Rank | County | 2024 Pop. |
|---|---|---|---|
| Rock Hill | 1 | York County | 75,971 |
| Fort Mill | 2 | Lancaster County | 36,438 |
| Lake Wylie | 3 | York County | 15,306 |
| Tega Cay | 4 | York County | 14,434 |
| York | 5 | York County | 9,353 |
| Lancaster | 6 | Lancaster County | 9,296 |
| Clover | 7 | York County | 7,608 |
| Chester | 8 | Chester County | 5,211 |
| Baxter Village | 9 | York County | 5,156 |
| India Hook | 10 | York County | 4,561 |
| Newport | 11 | York County | 4,241 |
| Lesslie | 12 | Chester County | 3,114 |
| Elgin | 13 | Kershaw County | 2,928 |
| Springdale | 14 | Lancaster County | 2,581 |
| Pageland | 15 | Chesterfield County | 2,514 |
| Riverview | 16 | York County | 2,232 |
| Kershaw | 17 | Lancaster County | 1,973 |
| Eureka Mill | 18 | Chester County | 1,958 |
| Irwin | 19 | Lancaster County | 1,945 |
| Great Falls | 20 | Chester County | 1,920 |
| Catawba | 21 | York County | 1,455 |
| Gayle Mill | 22 | Chester County | 1,110 |
| Van Wyck | 23 | Lancaster County | 1,028 |
| Fort Lawn | 24 | Chester County | 975 |
| Heath Springs | 25 | Lancaster County | 859 |
| Jefferson | 26 | Chesterfield County | 784 |
| Unity | 27 | Lancaster County | 738 |
| Buford | 28 | Lancaster County | 610 |
| Sharon | 29 | York County | 467 |
| McConnells | 30 | York County | 290 |
| Richburg | 31 | Chester County | 272 |
| Lowrys | 32 | Chester County | 182 |
| Tradesville | 33 | Lancaster County | 78 |
| Abney Crossroads | 34 | Kershaw County | 24 |