City | Rank | County | 2024 Pop. |
|---|---|---|---|
| Ontario | 1 | Malheur County | 11,907 |
| Nyssa | 2 | Malheur County | 3,267 |
| Burns | 3 | Harney County | 2,701 |
| Vale | 4 | Malheur County | 1,942 |
| John Day | 5 | Grant County | 1,656 |
| Hines | 6 | Harney County | 1,618 |
| Canyon City | 7 | Grant County | 652 |
| Mount Vernon | 8 | Grant County | 555 |
| Huntington | 9 | Baker County | 512 |
| Annex | 10 | Malheur County | 349 |
| Harper | 11 | Malheur County | 196 |
| Seneca | 12 | Grant County | 163 |
| Adrian | 13 | Malheur County | 156 |
| Juntura | 14 | Malheur County | 24 |
| Brogan | 15 | Malheur County | 19 |