14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Chickasha | 1 | 17,200 | 16,062 | 1.34% | 767 | 22.43 | City |
| Tuttle | 2 | 9,001 | 7,430 | 3.61% | 305 | 29.48 | City |
| Minco | 3 | 1,527 | 1,502 | 0.33% | 124 | 12.28 | City |
| Rush Springs | 4 | 1,015 | 997 | 0.4% | 873 | 1.16 | Town |
| Ninnekah | 5 | 822 | 784 | 0.98% | 81 | 10.18 | Town |
| Cole | 6 | 648 | 623 | 0.78% | 43 | 14.98 | Town |
| Verden | 7 | 517 | 509 | 0.39% | 1,329 | 0.39 | Town |
| Alex | 8 | 503 | 485 | 0.8% | 76 | 6.65 | Town |
| Amber | 9 | 462 | 417 | 1.99% | 117 | 3.95 | Town |
| Bridge Creek | 10 | 342 | 334 | 0.59% | 217 | 1.57 | Town |
| Pocasset | 11 | 188 | 185 | 0.53% | 69 | 2.71 | Town |
| Middleberg | 12 | 166 | 151 | 7.1% | 108 | 1.54 | CDP |
| Norge | 13 | 128 | 115 | 2.4% | 398 | 0.32 | Town |
| Bradley | 14 | 90 | 80 | 2.27% | 381 | 0.24 | Town |
Chickasha is the largest city in Grady County, with a population of 17,200.
Bradley is the smallest city in Grady County.
There are 14 cities in Grady County, Oklahoma.