18 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Salisbury | 1 | 33,250 | 33,022 | 0.14% | 2,408 | 13.81 | City |
| Fruitland | 2 | 6,095 | 5,529 | 1.89% | 1,581 | 3.85 | City |
| Delmar | 3 | 5,037 | 3,867 | 4.87% | 2,965 | 1.70 | Town |
| Pittsville | 4 | 1,639 | 1,633 | 0.06% | 1,051 | 1.56 | Town |
| Hebron | 5 | 1,102 | 1,109 | -0.09% | 840 | 1.31 | Town |
| Willards | 6 | 985 | 964 | 0.41% | 866 | 1.14 | Town |
| Sharptown | 7 | 701 | 693 | 0.29% | 1,653 | 0.42 | Town |
| Nanticoke | 8 | 382 | 228 | 2.69% | 145 | 2.63 | CDP |
| Mardela Springs | 9 | 352 | 356 | -0.28% | 867 | 0.41 | Town |
| Whitehaven | 10 | 204 | 168 | 7.37% | 553 | 0.37 | CDP |
| Quantico | 11 | 187 | 199 | 2.19% | 89 | 2.11 | CDP |
| Nanticoke Acres | 12 | 173 | 34 | 2.98% | 658 | 0.26 | CDP |
| Parsonsburg | 13 | 165 | 287 | -6.78% | 126 | 1.31 | CDP |
| Allen | 14 | 148 | 419 | -2.63% | 342 | 0.43 | CDP |
| Powellville | 15 | 128 | 109 | -3.03% | 81 | 1.57 | CDP |
| Bivalve | 16 | 82 | 122 | -8.89% | 56 | 1.45 | CDP |
| Tyaskin | 17 | 76 | 170 | -12.64% | 53 | 1.42 | CDP |
| Jesterville | 18 | 43 | 222 | -18.87% | 27 | 1.59 | CDP |
Salisbury is the largest city in Wicomico County, with a population of 33,250.
Jesterville is the smallest city in Wicomico County.
There are 18 cities in Wicomico County, Maryland.