20 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Dover-Foxcroft town | 1 | 4,517 | 4,423 | -0.24% | 67 | 67.81 | Town |
| Milo town | 2 | 2,384 | 2,252 | 0.46% | 72 | 32.98 | Town |
| Greenville town | 3 | 1,790 | 1,440 | 5.17% | 42 | 42.33 | Town |
| Sangerville town | 4 | 1,356 | 1,310 | -0.07% | 35 | 38.42 | Town |
| Guilford town | 5 | 1,304 | 1,265 | -0.15% | 37 | 34.88 | Town |
| Brownville town | 6 | 1,153 | 1,135 | -0.43% | 26 | 43.80 | Town |
| Parkman town | 7 | 767 | 746 | -0.26% | 17 | 45.23 | Town |
| Sebec town | 8 | 681 | 667 | -0.44% | 19 | 36.69 | Town |
| Monson town | 9 | 654 | 608 | 1.08% | 14 | 46.78 | Town |
| Abbot town | 10 | 645 | 650 | -0.15% | 19 | 34.53 | Town |
| Brownville Junction | 11 | 595 | 584 | 7.21% | 927 | 0.64 | CDP |
| Guilford | 12 | 448 | 494 | -6.28% | 234 | 1.92 | CDP |
| Shirley town | 13 | 290 | 253 | 2.84% | 5 | 53.33 | Town |
| Medford town | 14 | 238 | 232 | -0.42% | 6 | 42.31 | Town |
| Wellington town | 15 | 230 | 226 | -0.43% | 6 | 39.86 | Town |
| Lake View plantation | 16 | 156 | 151 | 0% | 4 | 40.89 | Plantation |
| Bowerbank town | 17 | 141 | 137 | 0% | 3 | 41.94 | Town |
| Willimantic town | 18 | 139 | 135 | 0% | 3 | 43.18 | Town |
| Beaver Cove town | 19 | 132 | 130 | -0.75% | 4 | 31.85 | Town |
| Kingsbury plantation | 20 | 32 | 31 | 0% | 1 | 44.12 | Plantation |
Dover-Foxcroft town is the largest city in Piscataquis County, with a population of 4,517.
Kingsbury plantation is the smallest city in Piscataquis County.
There are 20 cities in Piscataquis County, Maine.