10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Pueblo | 1 | 110,529 | 111,899 | -0.25% | 1,957 | 56.49 | City |
| Pueblo West | 2 | 35,512 | 32,842 | 1.12% | 716 | 49.61 | CDP |
| Colorado City | 3 | 1,867 | 2,200 | -1.11% | 124 | 15.01 | CDP |
| Salt Creek | 4 | 841 | 726 | 2.06% | 1,947 | 0.43 | CDP |
| Beulah Valley | 5 | 665 | 505 | 1.06% | 259 | 2.57 | CDP |
| Blende | 6 | 609 | 802 | -2.87% | 726 | 0.84 | CDP |
| Vineland | 7 | 442 | 339 | 2.79% | 781 | 0.57 | CDP |
| Boone | 8 | 310 | 307 | 0.32% | 818 | 0.38 | Town |
| Avondale | 9 | 305 | 588 | -7.58% | 486 | 0.63 | CDP |
| Rye | 10 | 200 | 207 | -0.5% | 2,128 | 0.09 | Town |
Pueblo is the largest city in Pueblo County, with a population of 110,529.
Rye is the smallest city in Pueblo County.
There are 10 cities in Pueblo County, Colorado.