10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Grand Junction | 1 | 71,870 | 65,725 | 1.74% | 1,769 | 40.62 | City |
| Clifton | 2 | 19,331 | 20,783 | -0.2% | 3,230 | 5.99 | CDP |
| Fruita | 3 | 14,077 | 13,424 | 0.94% | 1,758 | 8.01 | City |
| Redlands | 4 | 8,971 | 8,863 | 0.21% | 696 | 12.89 | CDP |
| Fruitvale | 5 | 8,109 | 8,352 | 0.36% | 2,836 | 2.86 | CDP |
| Orchard Mesa | 6 | 7,257 | 6,484 | 0.39% | 1,979 | 3.67 | CDP |
| Palisade | 7 | 2,624 | 2,569 | 0.42% | 2,209 | 1.19 | Town |
| Loma | 8 | 1,528 | 1,571 | 1.06% | 140 | 10.89 | CDP |
| De Beque | 9 | 468 | 490 | -0.85% | 169 | 2.78 | Town |
| Collbran | 10 | 363 | 370 | -0.27% | 651 | 0.56 | Town |
Grand Junction is the largest city in Mesa County, with a population of 71,870.
Collbran is the smallest city in Mesa County.
There are 10 cities in Mesa County, Colorado.