Note: As defined by the US Census Bureau, a city's official boundaries often extend miles beyond the city itself and may even cross county lines. As such, several thousand US cities officially exist in two or more counties (and therefore appear on multiple counties' lists of cities.)
City | Rank | 2024 Pop. | 2020 Pop. | Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Buffalo | 1 | 273,720 | 277,551 | -0.35% | 6,779 | 40.4 | City |
| Amherst | 2 | 131,279 | 129,353 | 0.17% | 2,468 | 53.2 | Town |
| Cheektowaga | 3 | 87,894 | 89,742 | -0.53% | 2,984 | 29.5 | Town |
| Tonawanda | 4 | 70,927 | 72,447 | -0.54% | 3,786 | 18.7 | Town |
| Hamburg | 5 | 59,879 | 60,059 | -0.18% | 1,449 | 41.3 | Town |
| Lancaster | 6 | 45,028 | 45,036 | -0.07% | 1,194 | 37.7 | Town |
| West Seneca | 7 | 45,007 | 45,475 | -0.22% | 2,104 | 21.4 | Town |
| Clarence | 8 | 33,195 | 32,947 | 0.23% | 620 | 53.5 | Town |
| Orchard Park | 9 | 29,718 | 29,669 | -0.11% | 773 | 38.4 | Town |
| Grand Island | 10 | 21,398 | 21,444 | -0.22% | 757 | 28.3 | Town |
| Lackawanna | 11 | 19,482 | 19,924 | -0.57% | 2,975 | 6.5 | City |
| Evans | 12 | 15,085 | 15,295 | -0.17% | 363 | 41.5 | Town |
| Kenmore | 13 | 14,829 | 15,177 | -0.58% | 10,327 | 1.4 | Village |
| Tonawanda | 14 | 14,824 | 15,124 | -0.5% | 3,898 | 3.8 | City |
| Depew | 15 | 14,804 | 15,152 | -0.58% | 2,916 | 5.1 | Village |
| Elma | 16 | 11,627 | 11,709 | -0.16% | 337 | 34.5 | Town |
| Alden | 17 | 10,080 | 9,670 | 1.52% | 294 | 34.3 | Town |
| Lancaster | 18 | 10,007 | 10,166 | -0.4% | 3,682 | 2.7 | Village |
| Hamburg | 19 | 9,741 | 9,751 | -0.03% | 3,929 | 2.5 | Village |
| Newstead | 20 | 8,618 | 8,690 | -0.28% | 170 | 50.8 | Town |
| Concord | 21 | 8,185 | 8,302 | -0.33% | 117 | 69.9 | Town |
| Boston | 22 | 7,899 | 7,947 | -0.35% | 221 | 35.8 | Town |
| Eden | 23 | 7,491 | 7,567 | -0.24% | 188 | 39.8 | Town |
| East Aurora | 24 | 5,943 | 5,974 | -0.13% | 2,367 | 2.5 | Village |
| Williamsville | 25 | 5,473 | 5,413 | 0.27% | 4,351 | 1.3 | Village |
| Marilla | 26 | 5,126 | 5,181 | -0.37% | 186 | 27.5 | Town |
| Springville | 27 | 4,136 | 4,210 | -0.46% | 1,124 | 3.7 | Village |
| Collins | 28 | 4,103 | 5,673 | -0.97% | 86 | 48.0 | Town |
| Sloan | 29 | 3,710 | 3,770 | -0.4% | 4,756 | 0.8 | Village |
| North Collins | 30 | 3,513 | 3,502 | 0.26% | 82 | 42.9 | Town |
| Holland | 31 | 3,239 | 3,276 | -0.34% | 91 | 35.8 | Town |
| Colden | 32 | 3,162 | 3,122 | 0.32% | 89 | 35.6 | Town |
| Orchard Park | 33 | 3,024 | 3,091 | -0.56% | 2,237 | 1.4 | Village |
| Wales | 34 | 2,992 | 3,008 | -0.17% | 84 | 35.6 | Town |
| Akron | 35 | 2,874 | 2,909 | -0.31% | 1,428 | 2.0 | Village |
| Sardinia | 36 | 2,685 | 2,715 | -0.33% | 53 | 50.2 | Town |
| Alden | 37 | 2,591 | 2,603 | -0.12% | 953 | 2.7 | Village |
| Blasdell | 38 | 2,533 | 2,537 | -0.04% | 2,254 | 1.1 | Village |
| Angola | 39 | 2,012 | 2,047 | -0.45% | 1,420 | 1.4 | Village |
| Brant | 40 | 1,930 | 1,914 | 0.26% | 79 | 24.3 | Town |
| North Collins | 41 | 1,266 | 1,260 | 0.08% | 1,581 | 0.8 | Village |
| Farnham | 42 | 362 | 366 | -0.27% | 300 | 1.2 | Village |
Note: City markers shown outside the county boundary mean that a part of the city extends into this county, but is primarily located in an adjacent county.
Buffalo is the largest city in Erie County.
Farnham is the smallest city in Erie County.
There are 42 cities in Erie County, New York.