Note: As defined by the US Census Bureau, a city's official boundaries often extend miles beyond the city itself and may even cross county lines. As such, several thousand US cities officially exist in two or more counties (and therefore appear on multiple counties' lists of cities.)
City | Rank | 2024 Pop. | 2020 Pop. | Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Port St. Lucie | 1 | 257,756 | 206,815 | 5.2% | 2,162 | 119.2 | City |
| Fort Pierce | 2 | 49,962 | 47,610 | 1.19% | 2,068 | 24.2 | City |
| Lakewood Park | 3 | 14,585 | 14,227 | 1.62% | 2,188 | 6.7 | CDP |
| Indian River Estates | 4 | 7,089 | 6,542 | 0.88% | 1,277 | 5.6 | CDP |
| Fort Pierce North | 5 | 6,526 | 7,199 | 0.05% | 1,541 | 4.2 | CDP |
| River Park | 6 | 6,347 | 7,139 | 1.29% | 2,699 | 2.4 | CDP |
| White City | 7 | 5,790 | 5,091 | 2.62% | 1,163 | 5.0 | CDP |
| Fort Pierce South | 8 | 5,356 | 4,468 | 0.39% | 2,066 | 2.6 | CDP |
| St. Lucie Village | 9 | 603 | 610 | -0.33% | 671 | 0.9 | Town |
Note: City markers shown outside the county boundary mean that a part of the city extends into this county, but is primarily located in an adjacent county.
Port St. Lucie is the largest city in St. Lucie County.
St. Lucie Village is the smallest city in St. Lucie County.
There are 9 cities in St. Lucie County, Florida.