4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Gaffney | 1 | 12,312 | 12,742 | -0.69% | 1,373 | 8.97 | City |
| East Gaffney | 2 | 2,944 | 3,043 | -0.3% | 974 | 3.02 | CDP |
| Blacksburg | 3 | 1,929 | 1,886 | 0.47% | 1,031 | 1.87 | Town |
| Central Pacolet | 4 | 240 | 209 | 2.56% | 1,017 | 0.24 | Town |
Gaffney is the largest city in Cherokee County, with a population of 12,312.
Central Pacolet is the smallest city in Cherokee County.
There are 4 cities in Cherokee County, South Carolina.