24 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Roseburg | 1 | 23,983 | 23,678 | 0.25% | 2,230 | 10.76 | City |
| Sutherlin | 2 | 8,732 | 8,532 | 0.46% | 1,429 | 6.11 | City |
| Green | 3 | 8,310 | 8,149 | 0.64% | 1,824 | 4.55 | CDP |
| Winston | 4 | 5,706 | 5,635 | 0.25% | 2,067 | 2.76 | City |
| Reedsport | 5 | 4,321 | 4,320 | 0% | 2,087 | 2.07 | City |
| Roseburg North | 6 | 4,120 | 4,328 | -2.81% | 2,271 | 1.81 | CDP |
| Tri-City | 7 | 3,780 | 4,449 | -0.26% | 520 | 7.27 | CDP |
| Myrtle Creek | 8 | 3,516 | 3,478 | 0.23% | 1,407 | 2.50 | City |
| Canyonville | 9 | 1,674 | 1,644 | 0.36% | 1,579 | 1.06 | City |
| Glide | 10 | 1,455 | 1,287 | -1.56% | 144 | 10.08 | CDP |
| Riddle | 11 | 1,231 | 1,213 | 0.33% | 1,939 | 0.64 | City |
| Drain | 12 | 1,206 | 1,175 | 0.5% | 1,905 | 0.63 | City |
| Yoncalla | 13 | 1,052 | 1,017 | 0.67% | 1,565 | 0.67 | City |
| Oakland | 14 | 961 | 935 | 0.52% | 1,316 | 0.73 | City |
| Glendale | 15 | 868 | 857 | 0.23% | 2,214 | 0.39 | City |
| Melrose | 16 | 812 | 544 | 0.62% | 187 | 4.35 | CDP |
| Lookingglass | 17 | 739 | 862 | -0.94% | 64 | 11.58 | CDP |
| Gardiner | 18 | 286 | 466 | 1.06% | 496 | 0.58 | CDP |
| Dillard | 19 | 276 | 525 | -4.5% | 234 | 1.18 | CDP |
| Winchester Bay | 20 | 201 | 319 | -5.63% | 76 | 2.65 | CDP |
| Elkton | 21 | 189 | 184 | 0.53% | 815 | 0.23 | City |
| Fair Oaks | 22 | 186 | 132 | -3.13% | 101 | 1.84 | CDP |
| Beaver Marsh | 23 | 145 | 160 | 7.41% | 445 | 0.33 | CDP |
| Days Creek | 24 | 136 | 301 | -6.21% | 58 | 2.36 | CDP |
Roseburg is the largest city in Douglas County, with a population of 23,983.
Days Creek is the smallest city in Douglas County.
There are 24 cities in Douglas County, Oregon.