21 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Plattsmouth | 1 | 6,947 | 6,599 | 1.02% | 2,095 | 3.32 | City |
| Union township | 2 | 2,092 | 1,956 | 0.97% | 80 | 26.24 | Township |
| Louisville | 3 | 1,457 | 1,334 | 1.75% | 2,188 | 0.67 | City |
| Eagle | 4 | 1,285 | 1,089 | 3.13% | 3,024 | 0.42 | Village |
| Weeping Water | 5 | 1,077 | 1,039 | 0.75% | 1,029 | 1.05 | City |
| Elmwood | 6 | 695 | 669 | 0.72% | 1,541 | 0.45 | Village |
| Greenwood | 7 | 621 | 595 | 0.81% | 1,511 | 0.41 | Village |
| Murray | 8 | 509 | 486 | 0.99% | 1,454 | 0.35 | Village |
| Cedar Creek | 9 | 481 | 463 | 0.84% | 918 | 0.52 | Village |
| Woodland Hills | 10 | 321 | 206 | 2.23% | 897 | 0.36 | CDP |
| Murdock | 11 | 281 | 270 | 0.72% | 2,051 | 0.14 | Village |
| Union township | 12 | 232 | 247 | -1.28% | 5 | 48.17 | Township |
| Union township | 13 | 216 | 211 | 0.47% | 6 | 35.92 | Township |
| Union | 14 | 201 | 195 | 0.5% | 1,063 | 0.19 | Village |
| Avoca | 15 | 185 | 179 | 0.54% | 1,312 | 0.14 | Village |
| Manley | 16 | 178 | 170 | 1.14% | 1,548 | 0.12 | Village |
| Nehawka | 17 | 175 | 169 | 0.57% | 714 | 0.24 | Village |
| Alvo | 18 | 117 | 114 | 0.86% | 854 | 0.14 | Village |
| Wann | 19 | 116 | 69 | 7.41% | 78 | 1.49 | CDP |
| South Bend | 20 | 96 | 90 | 1.05% | 1,129 | 0.09 | Village |
| Union township | 21 | 79 | 74 | 2.6% | 2 | 34.66 | Township |
Plattsmouth is the largest city in Cass County, with a population of 6,947.
Union township is the smallest city in Cass County.
There are 21 cities in Cass County, Nebraska.