Wuppertal's 2025 population is now estimated at 348,119. In 1950, the population of Wuppertal was 364,456. Wuppertal has grown by 2 in the last year, which represents a 0% annual change.These population estimates and projections come from the latest revision of the UN World Urbanization Prospects. These estimates represent the Urban agglomeration of Wuppertal, which typically includes Wuppertal's population in addition to adjacent suburban areas.