
St. Francois County
- State:
- Missouri
- County Seat:
- Farmington
St. Francois County's estimated 2025 population is 67,362 with a growth rate of 0.23% in the past year according to the most recent United States census data. St. Francois County is the 18th largest county in Missouri. The 2010 population was 65,534 and has seen a growth of 2.79% since that time.