25 cities
| City | Rank | County | 2025 Pop. ↓ |
|---|---|---|---|
| Charleston | 1 | Kanawha County | 45,636 |
| South Charleston | 2 | Kanawha County | 12,905 |
| St. Albans | 3 | Kanawha County | 10,095 |
| Dunbar | 4 | Kanawha County | 6,971 |
| Nitro | 5 | Kanawha County | 6,291 |
| Spencer | 6 | Roane County | 1,948 |
| Marmet | 7 | Kanawha County | 1,399 |
| Chesapeake | 8 | Kanawha County | 1,260 |
| Belle | 9 | Kanawha County | 1,074 |
| Glenville | 10 | Gilmer County | 1,053 |
| Clendenin | 11 | Kanawha County | 868 |
| Sutton | 12 | Braxton County | 819 |
| East Bank | 13 | Kanawha County | 772 |
| Gassaway | 14 | Braxton County | 720 |
| Cedar Grove | 15 | Kanawha County | 673 |
| Glasgow | 16 | Kanawha County | 672 |
| West Union | 17 | Doddridge County | 630 |
| Grantsville | 18 | Calhoun County | 456 |
| Pratt | 19 | Kanawha County | 447 |
| Burnsville | 20 | Braxton County | 371 |
| Clay | 21 | Clay County | 361 |
| Flatwoods | 22 | Braxton County | 253 |
| Handley | 23 | Kanawha County | 208 |
| Sand Fork | 24 | Gilmer County | 172 |
| Reedy | 25 | Roane County | 143 |
Kanawha County, Roane County, Braxton County, Clay County, Doddridge County, Gilmer County, and Calhoun County are the counties generally considered part of Central West Virginia.