
Irene
- County:
- Clay County
- County Seat:
- No
- Area (mi²):
- 0.255
- State:
- South Dakota
Irene is a city located in Clay County, South Dakota. Irene has a 2025 population of 440. Irene is currently growing at a rate of 0.69% annually and its population has increased by 3.04% since the most recent census, which recorded a population of 427 in 2020.
The average household income in Irene is $67,036 with a poverty rate of 14.99%. The median age in Irene is 37.3 years: 35.3 years for males, and 38.5 years for females.