19 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Rock Hill | York County | 76,289 |
| Red Hill | Horry County | 16,176 |
| Red Bank | Lexington County | 10,776 |
| Roebuck | Spartanburg County | 4,246 |
| Ridgeland | Jasper County | 3,753 |
| Ravenel | Charleston County | 2,701 |
| Riverview | York County | 2,342 |
| Reidville | Spartanburg County | 1,878 |
| Ridgeville | Dorchester County | 1,498 |
| Ridge Spring | Saluda County | 585 |
| Ruby | Chesterfield County | 324 |
| Richburg | Chester County | 270 |
| Ridgeway | Fairfield County | 249 |
| Rowesville | Orangeburg County | 243 |
| Rembert | Sumter County | 242 |
| Russellville | Berkeley County | 228 |
| Reevesville | Dorchester County | 190 |
| Rockville | Charleston County | 139 |
| Rains | Marion County | 123 |