25 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Mount Pleasant | Charleston County | 97,903 |
| Myrtle Beach | Horry County | 42,179 |
| Mauldin | Greenville County | 30,166 |
| Moncks Corner | Berkeley County | 18,743 |
| Murrells Inlet | Horry County | 10,984 |
| Marion | Marion County | 6,047 |
| Mullins | Marion County | 3,803 |
| Manning | Clarendon County | 3,762 |
| Mayo | Spartanburg County | 2,008 |
| McCormick | Edgefield County | 1,983 |
| McColl | Marlboro County | 1,943 |
| Monarch Mill | Union County | 1,755 |
| Murphys Estates | Aiken County | 1,486 |
| Meggett | Charleston County | 1,455 |
| Manville | Kershaw County | 823 |
| McBee | Chesterfield County | 798 |
| Modoc | McCormick County | 698 |
| McClellanville | Charleston County | 626 |
| Mayesville | Sumter County | 539 |
| Mount Carmel | McCormick County | 420 |
| McConnells | York County | 292 |
| Monetta | Aiken County | 208 |
| Mountville | Laurens County | 142 |
| Mount Croghan | Chesterfield County | 133 |
| Mulberry | Sumter County | 98 |