18 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Florence | Florence County | 40,950 |
| Fort Mill | Lancaster County | 39,251 |
| Five Forks | Greenville County | 19,705 |
| Fountain Inn | Greenville County | 14,702 |
| Forest Acres | Richland County | 10,239 |
| Forestbrook | Horry County | 8,114 |
| Folly Beach | Charleston County | 2,085 |
| Fairforest | Spartanburg County | 1,609 |
| Fairfax | Allendale County | 1,315 |
| Fort Lawn | Chester County | 978 |
| Fripp Island | Beaufort County | 959 |
| Fairview Crossroads | Lexington County | 735 |
| Finklea | Horry County | 649 |
| Fair Play | Oconee County | 546 |
| Furman | Hampton County | 220 |
| Floydale | Dillon County | 174 |
| Foreston | Clarendon County | 166 |
| Fingerville | Spartanburg County | 90 |