19 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Easley | Pickens County | 28,620 |
| East Camden | Kershaw County | 4,480 |
| Edgefield | Edgefield County | 4,145 |
| Elgin | Kershaw County | 2,951 |
| East Gaffney | Cherokee County | 2,944 |
| Eureka Mill | Chester County | 1,992 |
| Edisto | Orangeburg County | 1,740 |
| Estill | Hampton County | 1,736 |
| Elgin | Kershaw County | 1,654 |
| Edmund | Lexington County | 1,436 |
| Edisto Beach | Charleston County | 1,062 |
| Elliott | Lee County | 698 |
| East Sumter | Lee County | 651 |
| Eastover | Richland County | 623 |
| Elloree | Orangeburg County | 538 |
| Ehrhardt | Bamberg County | 434 |
| Enoree | Spartanburg County | 385 |
| Eutawville | Orangeburg County | 233 |
| Elko | Barnwell County | 141 |