18 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Dentsville | Richland County | 16,983 |
| Dillon | Dillon County | 6,172 |
| Darlington | Darlington County | 5,967 |
| Duncan | Spartanburg County | 4,675 |
| Dalzell | Sumter County | 3,507 |
| Dunean | Greenville County | 3,366 |
| Denmark | Bamberg County | 3,055 |
| Dunbar | Georgetown County | 1,324 |
| Drayton | Spartanburg County | 1,264 |
| Due West | Abbeville County | 1,216 |
| Dale | Beaufort County | 1,196 |
| Dovesville | Darlington County | 1,185 |
| DeBordieu Colony | Georgetown County | 870 |
| Daufuskie Island | Beaufort County | 711 |
| Danwood | Florence County | 588 |
| Donalds | Abbeville County | 322 |
| Daviston | Marion County | 308 |
| Dacusville | Pickens County | 272 |