18 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Aiken | Aiken County | 33,485 |
| Anderson | Anderson County | 30,316 |
| Abbeville | Abbeville County | 4,863 |
| Arthurtown | Richland County | 3,759 |
| Arkwright | Spartanburg County | 3,236 |
| Arcadia | Spartanburg County | 2,899 |
| Andrews | Georgetown County | 2,517 |
| Allendale | Allendale County | 2,362 |
| Arial | Pickens County | 1,552 |
| Awendaw | Charleston County | 1,479 |
| Aynor | Horry County | 1,097 |
| Arcadia Lakes | Richland County | 846 |
| Adams Run | Charleston County | 559 |
| Atlantic Beach | Horry County | 458 |
| Alcolu | Clarendon County | 374 |
| Antreville | Abbeville County | 323 |
| Ashwood | Kershaw County | 79 |
| Abney Crossroads | Kershaw County | 26 |