22 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Durham | Durham County | 304,014 |
| Davidson | Mecklenburg County | 14,098 |
| Dunn | Harnett County | 8,683 |
| Dallas | Gaston County | 6,290 |
| Dana | Henderson County | 3,704 |
| Denver | Lincoln County | 2,847 |
| Dudley | Wayne County | 2,495 |
| Drexel | Burke County | 1,762 |
| Denton | Davidson County | 1,594 |
| Dobson | Surry County | 1,462 |
| Dortches | Nash County | 1,129 |
| Duck | Dare County | 744 |
| Dobbins Heights | Richmond County | 681 |
| Deep Run | Lenoir County | 605 |
| Deercroft | Scotland County | 457 |
| Dover | Craven County | 354 |
| Dublin | Bladen County | 260 |
| Davis | Carteret County | 238 |
| Dillsboro | Jackson County | 218 |
| Danbury | Stokes County | 186 |
| Delco | Columbus County | 67 |
| Dundarrach | Hoke County | 65 |