
Santee
- County:
- Knox County
- County Seat:
- No
- Area (mi²):
- 0.564
- State:
- Nebraska
Santee is a village located in Knox County, Nebraska. Santee has a 2025 population of 425. Santee is currently growing at a rate of 0.24% annually and its population has increased by 0.71% since the most recent census, which recorded a population of 422 in 2020.
The average household income in Santee is $50,243 with a poverty rate of 37%. The median age in Santee is 20.8 years: 18.6 years for males, and 26 years for females.