
Sikeston
- County:
- Scott County
- County Seat:
- No
- Area (mi²):
- 17.151
- State:
- Missouri
Sikeston is a city located in Scott County, Missouri. Sikeston has a 2025 population of 15,967. Sikeston is currently declining at a rate of -0.37% annually and its population has decreased by -1.81% since the most recent census, which recorded a population of 16,262 in 2020.
The average household income in Sikeston is $74,453 with a poverty rate of 16.55%. The median age in Sikeston is 37 years: 33.8 years for males, and 39.2 years for females.