
Mayersville
- County:
- Issaquena County
- County Seat:
- Yes
- Area (mi²):
- 1.101
- State:
- Mississippi
Mayersville is a town located in Issaquena County, Mississippi. Mayersville has a 2025 population of 391. It is also the county seat of Issaquena County. Mayersville is currently declining at a rate of -2.01% annually and its population has decreased by -9.28% since the most recent census, which recorded a population of 431 in 2020.
The average household income in Mayersville is $27,683 with a poverty rate of 33.66%. The median age in Mayersville is 51.8 years: 49.7 years for males, and 54.4 years for females.