
De Kalb
- County:
- Kemper County
- County Seat:
- Yes
- Area (mi²):
- 3.319
- State:
- Mississippi
De Kalb is a town located in Kemper County, Mississippi. De Kalb has a 2025 population of 811. It is also the county seat of Kemper County. De Kalb is currently declining at a rate of -1.58% annually and its population has decreased by -7.31% since the most recent census, which recorded a population of 875 in 2020.
The average household income in De Kalb is $56,496 with a poverty rate of 24.82%. The median age in De Kalb is 40.3 years: 37.9 years for males, and 44 years for females.