21 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Cambridge city | Middlesex County | 119,802 |
| Chicopee city | Hampden County | 54,636 |
| Chelsea city | Suffolk County | 37,753 |
| Chelmsford town | Middlesex County | 36,352 |
| Canton town | Norfolk County | 24,649 |
| Concord town | Middlesex County | 18,152 |
| Clinton town | Worcester County | 15,636 |
| Charlton town | Worcester County | 13,393 |
| Carver town | Plymouth County | 11,767 |
| Cohasset town | Norfolk County | 8,472 |
| Chatham town | Barnstable County | 6,649 |
| Carlisle town | Middlesex County | 5,212 |
| Cheshire town | Berkshire County | 3,147 |
| Conway town | Franklin County | 1,760 |
| Colrain town | Franklin County | 1,647 |
| Clarksburg town | Berkshire County | 1,628 |
| Chilmark town | Dukes County | 1,222 |
| Chester town | Hampden County | 1,201 |
| Charlemont town | Franklin County | 1,167 |
| Chesterfield town | Hampshire County | 1,163 |
| Cummington town | Hampshire County | 817 |